Marine Drugs | |
Influence of Lipid A Acylation Pattern on Membrane Permeability and Innate Immune Stimulation | |
Yanyan Li1  Zhou Wang1  Jiuzhou Chen1  Robert K. Ernst2  | |
[1] State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; E-Mails:;Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, MD 21201, USA; E-Mail: | |
关键词: endotoxin; lipid A; lipopolysaccharide; TLR4/MD2; membrane permeability; PagL; | |
DOI : 10.3390/md11093197 | |
来源: mdpi | |
【 摘 要 】
Lipid A, the hydrophobic anchor of lipopolysaccharide (LPS), is an essential component in the outer membrane of Gram-negative bacteria. It can stimulate the innate immune system via Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD2), leading to the release of inflammatory cytokines. In this study, six
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190033746ZK.pdf | 352KB | download |