The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation

Molecules

Huei-Ping Dong²  Hui-Ming Wu¹  Sheue-Jiun Chen¹ 

[1] Department of Health Beauty, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan; E-Mails:;Department of Physical Therapy, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan

关键词: Cinnamomum tenuifolium;    isotenuifolide;    tenuifolide B;    platelet aggregation;   

DOI  :  10.3390/molecules181011836

来源: mdpi

【 摘 要 】

This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate (ADP)-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide (1 and 2 μg/μL) and tenuifolide B (1, 2 and 4 μg/μL) did not have any significant effect on human platelet aggregation in vitro, however, treatment of human platelet-rich plasma with isotenuifolide (4 μg/μL) resulted in an inhibitory effect on platelet aggregation, suggesting the potential of this compound as an anti-atherosclerogenic agent in humans. Isotenuifolide is a new butanolide compound, whose structure was characterized by spectral analyses.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.