An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs

Molecules

Xiu-Yan Yang²  Guang-Qiang Xia¹  Xiao-Kui Wang¹  Zhi-Bing Zheng¹  Dong-Mei Zhao¹  Guo-Ming Zhao¹ 

[1] Department of Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China;School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China

关键词: anti-HBV;    enantiopure;    (R)-heteroarylpyrimidines;    chiral separation;    diastereomer;   

DOI  :  10.3390/molecules180911144

来源: mdpi

【 摘 要 】

An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.