Astataricusones A–D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.

Molecules

Wen-Bing Zhou¹  Guang-Zhi Zeng¹  Hui-Min Xu¹  Wen-Jun He¹ 

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650201, China; E-Mails:

关键词: Aster tataricus;    shionane-type triterpenes;    astataricusones A–D;    astataricusol A;    anti-HBV;   

DOI  :  10.3390/molecules181214585

来源: mdpi

【 摘 要 】

Five new shionane-type triterpenes, astataricusones A–D (compounds 1–4) and astataricusol A (5), together with one known shionane-type triterpene 6 were obtained from the roots and rhizomes of Aster tataricus L. f. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configurations of 1 and 4 was determined by single crystal X-ray diffraction and CD analysis. Compound 2 showed inhibitory activity on HBsAg secretion with an IC₅₀ value of 23.5 μM, while 2 and 6 showed inhibitory activities on HBeAg secretion with IC₅₀ values of 18.6 and 40.5 μM, and cytotoxicity on HepG 2.2.15 cells with CC₅₀ values of 172.4 and 137.7 μM, respectively. Compounds 2 and 6 also exhibited inhibitory activities on HBV DNA replication with IC₅₀ values of 2.7 and 30.7 μM, respectively.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.