A Facile and Efficient Synthesis of Diaryl Amines or Ethers under Microwave Irradiation at Presence of KF/Al2O3 without Solvent and Their Anti-Fungal Biological Activities against Six Phytopathogens

International Journal of Molecular Sciences

Liang-Zhu Huang¹  Pan Han¹  You-Qiang Li¹  Ying-Meng Xu¹  Tao Zhang¹ 

[1] College of Science, Northwest A & F University, Yangling 712100, China; E-Mails:

关键词: microwave-assisted organic synthesis;    diaryl amine;    diaryl ether;    KF/Al₂O₃;   

DOI  :  10.3390/ijms140918850

来源: mdpi

【 摘 要 】

A series of diaryl amines, ethers and thioethers were synthesized under microwave irradiation efficiently at presence of KF/Al₂O₃ in 83%–96% yields without any solvent. The salient characters of this method lie in short reaction time, high yields, general applicability to substrates and simple workup procedure. At the same time, their antifungal biological activities against six phytopathogen were evaluated. Most of the compounds (3b, 3c, 3g–o) are more potent than thiophannate-methyl against to Magnaporthe oryzae. This implies that diaryl amine or ether moiety may be helpful in finding a fungicide against Magnaporthe oryzae.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland