Glycosyl-Nucleolipids as New Bioinspired Amphiphiles

Molecules

Laurent Latxague¹  Amit Patwa¹  Eric Amigues¹ 

[1] INSERM U869, Bordeaux, F-33076, France

关键词: nucleolipid;    nucleoside;    glycosyl;    fluorocarbon;    amphiphiles;    surface tension;   

DOI  :  10.3390/molecules181012241

来源: mdpi

【 摘 要 】

Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower γ_lim) compared to the first generation of GNFs.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.