Molecules | |
Glycosyl-Nucleolipids as New Bioinspired Amphiphiles | |
Laurent Latxague1  Amit Patwa1  Eric Amigues1  | |
[1] INSERM U869, Bordeaux, F-33076, France | |
关键词: nucleolipid; nucleoside; glycosyl; fluorocarbon; amphiphiles; surface tension; | |
DOI : 10.3390/molecules181012241 | |
来源: mdpi | |
【 摘 要 】
Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower γlim) compared to the first generation of GNFs.
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190033181ZK.pdf | 416KB | download |