Semisynthesis and Antifeedant Activity of New Derivatives of a Dihydro-β-Agarofuran from Parnassia wightiana

International Journal of Molecular Sciences

Jiang-Jiang Tang²  Fei-Yu Zhang²  Dong-Mei Wang¹  Jun-Mian Tian²  Shuai Dong² 

[1] College of Forestry, Northwest A&F University, Yangling 712100, Shaanxi, China; E-Mail:;Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China; E-Mails:

关键词: sesquiterpene;    agarofuran;    derivatives;    antifeedant activity;   

DOI  :  10.3390/ijms141019484

来源: mdpi

【 摘 要 】

Five new derivatives (2–6) were semi-synthesized using compound 1, a dihydro-β-agarofuran sesquiterpene with C-2 ketone obtained from Parnassia wightiana, as the starting material by acylation, oxidation, reduction, esterification, and amination, respectively. Structures of 2–6 were confirmed by 1D- and 2D-NMR and HR-ESI-MS spectra. In addition, antifeedant activities of these compounds (1–6) were tested against the 3rd-instar larvae of Mythimna separata. Antifeedant effects of compounds 2 and 4 were greater than the parent compound 1 whereas other compounds exhibited low to no feeding deterrent effects against third instar M. separata larvae in lab bioassays. Therefore, our results suggest that acylated and reduced derivatives at C-8 and C-2, respectively, of 1 may improve the antifeeding effect. This preliminary information will be useful in designing new insect control agents against M. separata and other important pests.

【 授权许可】

CC BY   
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