A Hybrid Methacrylate-Sodium Carboxymethylcellulose Interpolyelectrolyte Complex: Rheometry and in Silico Disposition for Controlled Drug Release

Materials

Ndidi Chinyelu Ngwuluka²  Yahya Essop Choonara²  Pradeep Kumar²  Girish Modi¹  Lisa Claire du Toit² 

[1] Faculty of Health Sciences, Division of Neurosciences, Department of Neurology, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa; E-Mail:;Faculty of Health Sciences, Department of Pharmacy and Pharmacology, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa; E-Mails:

关键词: interpolyelectrolyte complex;    eudragit;    carboxymethylcellulose;    rheology;    hydrogel;    molecular mechanics;   

DOI  :  10.3390/ma6104284

来源: mdpi

【 摘 要 】

The rheological behavioral changes that occurred during the synthesis of an interpolyelectrolyte complex (IPEC) of methacrylate copolymer and sodium carboxymethylcellulose were assessed. These changes were compared with the rheological behavior of the individual polymers employing basic viscosity, yield stress, stress sweep, frequency sweep, temperature ramp as well as creep and recovery testing. The rheological studies demonstrated that the end-product of the complexation of low viscous methacrylate copolymer and entangled solution of sodium carboxymethylcellulose generated a polymer, which exhibited a solid-like behavior with a three-dimensional network. Additionally, the rheological profile of the sodium carboxymethylcellulose and methacrylate copolymer with respect to the effect of various concentrations of acetic acid on the synthesis of the IPEC was elucidated using molecular mechanics energy relationships (MMER) by exploring the spatial disposition of carboxymethylcellulose and methacrylate copolymer with respect to each other and acetic acid. The computational results corroborated well with the experimental in vitro drug release data. Results have shown that the IPEC may be suitable polymeric material for achieving controlled zero-order drug delivery.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.