Molecules | |
Identification of New Natural DNA G-Quadruplex Binders Selected by a Structure-Based Virtual Screening Approach | |
Anna Artese1  Giosuè Costa1  Francesco Ortuso1  Lucia Parrotta1  | |
[1] id="af1-molecules-18-12051">Dipartimento di Scienze della Salute, Università degli Studi “Magna Græcia”, Campus “S. Venuta”, Viale Europa, Germaneto, Catanzaro 88100, Ita | |
关键词: DNA; G-quadruplex; PDB; pharmacophore; natural compounds; virtual screening; docking; | |
DOI : 10.3390/molecules181012051 | |
来源: mdpi | |
【 摘 要 】
The G-quadruplex DNA structures are mainly present at the terminal portion of telomeres and can be stabilized by ligands able to recognize them in a specific manner. The recognition process is usually related to the inhibition of the enzyme telomerase indirectly involved and over-expressed in a high percentage of human tumors. There are several ligands, characterized by different chemical structures, already reported in the literature for their ability to bind and stabilize the G-quadruplex structures. Using the structural and biological information available on these structures; we performed a high throughput
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190032793ZK.pdf | 2353KB | download |