Twist and miR-34a Are Involved in the Generation of Tumor-Educated Myeloid-Derived Suppressor Cells

International Journal of Molecular Sciences

Xin Wang¹  Xusheng Chang²  Guangzuan Zhuo³  Mingjuan Sun⁴ 

[1] Department of General Surgery, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China; E-Mail:;Department of General Surgery, Yancheng City First People’s Hospital, Yancheng City 224000, Jiangsu, China; E-Mail:;Department of Colorectal Surgery, the Second Artillery General Hospital of PLA, Beijing 10008, China; E-Mail:;Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai 200433, China

关键词: myeloid-derived suppressor cells;    twist;    miR-34a;    dendritic cells;    tumor escape;   

DOI  :  10.3390/ijms141020459

来源: mdpi

【 摘 要 】

Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells in the tumor microenvironment, contributing to tumor immunological escapes. Many studies have demonstrated that multiple factors could induce myeloid precursor cells into myeloid-derived suppressor cells, not dendritic cells. In our study, we found that tumor supernatants could induce the generation of myeloid-derived suppressor cells by disturbing the development of dendritic cells. Twist and miR-34a may regulate the effect of tumor cells inducing myeloid-derived suppressor cells via TGF-β and/or IL-10.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland