期刊论文详细信息
International Journal of Molecular Sciences
N,N′-alkylated Imidazolium-Derivatives Act as Quorum-Sensing Inhibitors Targeting the Pectobacterium atrosepticum-Induced Symptoms on Potato Tubers
Yannick Raoul des Essarts1  Mohamad Sabbah3  Arnaud Comte2  Laurent Soulère3  Yves Queneau3  Yves Dessaux1  Valérie Hélias4 
[1] Centre National de la Recherche Scientifique, Institut des Sciences du Végétal, UPR 2355, Gif-sur-Yvette 91198, France; E-Mails:;Service de Chimiothèque, ICBMS, UMR 5246, CNRS, Université Lyon 1, INSA-Lyon, CPE-Lyon, Bât Curien, 43 bd du 11 Novembre 1918, 69622 Villeurbanne Cedex, France; E-Mail:;INSA Lyon, ICBMS, UMR 5246, CNRS, Université Lyon 1, INSA-Lyon, CPE-Lyon, Bât J. Verne, 20 av A. Einstein, 69621 Villeurbanne Cedex, France; E-Mails:;FN3PT/RD3PT, Fédération Nationale des Producteurs de Plants de Pomme de terre, 43-45 Rue de Naples, Paris F-75008, France; E-Mail:
关键词: N-acylhomoserine lactone;    quorum-sensing;    quorum-sensing inhibitor;    Pectobacterium;    soft-rot;    potato tuber;   
DOI  :  10.3390/ijms141019976
来源: mdpi
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【 摘 要 】

Bacteria belonging to the Pectobacterium genus are the causative agents of the blackleg and soft-rot diseases that affect potato plants and tubers worldwide. In Pectobacterium, the expression of the virulence genes is controlled by quorum-sensing (QS) and N-acylhomoserine lactones (AHLs). In this work, we screened a chemical library of QS-inhibitors (QSIs) and AHL-analogs to find novel QSIs targeting the virulence of Pectobacterium. Four N,N′-bisalkylated imidazolium salts were identified as QSIs; they were active at the μM range. In potato tuber assays, two of them were able to decrease the severity of the symptoms provoked by P. atrosepticum. This work extends the range of the QSIs acting on the Pectobacterium-induced soft-rot disease.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland

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