Trypanocidal Activity of Marine Natural Products

Marine Drugs

Amy J. Jones¹  Tanja Grkovic¹  Melissa L. Sykes¹ 

[1] Eskitis Institute for Drug Discovery, Griffith University, Nathan, Brisbane 4111, Australia;

关键词: human African trypanosomiasis;    sleeping sickness;    chagas disease;    marine natural products;    drug discovery;   

DOI  :  10.3390/md11104058

来源: mdpi

【 摘 要 】

Marine natural products are a diverse, unique collection of compounds with immense therapeutic potential. This has resulted in these molecules being evaluated for a number of different disease indications including the neglected protozoan diseases, human African trypanosomiasis and Chagas disease, for which very few drugs are currently available. This article will review the marine natural products for which activity against the kinetoplastid parasites; Trypanosoma brucei brucei, T.b. rhodesiense and T. cruzi has been reported. As it is important to know the selectivity of a compound when evaluating its trypanocidal activity, this article will only cover molecules which have simultaneously been tested for cytotoxicity against a mammalian cell line. Compounds have been grouped according to their chemical structure and representative examples from each class were selected for detailed discussion.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.