International Journal of Molecular Sciences | |
RNA-Binding Proteins Impacting on Internal Initiation of Translation | |
Encarnación Martínez-Salas1  Gloria Lozano2  Javier Fernandez-Chamorro2  Rosario Francisco-Velilla2  Alfonso Galan2  | |
[1] Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049, Spain; | |
关键词: RNA-binding proteins; internal initiation of translation; IRES elements; | |
DOI : 10.3390/ijms141121705 | |
来源: mdpi | |
【 摘 要 】
RNA-binding proteins (RBPs) are pivotal regulators of all the steps of gene expression. RBPs govern gene regulation at the post-transcriptional level by virtue of their capacity to assemble ribonucleoprotein complexes on certain RNA structural elements, both in normal cells and in response to various environmental stresses. A rapid cellular response to stress conditions is triggered at the step of translation initiation. Two basic mechanisms govern translation initiation in eukaryotic mRNAs, the cap-dependent initiation mechanism that operates in most mRNAs, and the internal ribosome entry site (IRES)-dependent mechanism activated under conditions that compromise the general translation pathway. IRES elements are
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland
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