Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN

International Journal of Molecular Sciences

Feng Xie³  Ming Su¹  Wei Qiu³  Min Zhang²  Zhongqiang Guo³  Boxing Su³  Jie Liu³  Xuesong Li³ 

[1] Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, FuWai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China; E-Mail:;Department of Urology, Shanxi Medical University First Hospital, Taiyuan 030001, China; E-Mail:;Department of Urology, Peking University First Hospital & the Institute of Urology, Peking University, Beijing 100034, China; E-Mails:

关键词: kaempferol;    bladder cancer;    apoptosis;    PTEN;    Akt;   

DOI  :  10.3390/ijms141121215

来源: mdpi

【 摘 要 】

Kaempferol (Kae), a natural flavonoid, is widely distributed in fruits and vegetables. Previous studies have identified Kae as a possible cancer preventive and therapeutic agent. We found Kae to exhibit potent antiproliferation and anti-migration effects in human bladder cancer EJ cells. Kaempferol robustly induced apoptosis in EJ cells in a dose-dependent manner, as evidenced by increased cleavage of caspase-3. Furthermore, we found Kae-induced apoptosis in EJ cells to be associated with phosphatase and the tensin homolog deleted on the chromosome 10 (PTEN)/PI3K/Akt pathway. Kae significantly increased PTEN and decreased Akt phosphorylation. Kae-induced apoptosis was partially attenuated in PTEN-knockdown cells. Our findings indicate that Kae could be an alternative medicine for bladder cancer, based on a PTEN activation mechanism.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland