International Journal of Molecular Sciences | |
Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN | |
Feng Xie3  Ming Su1  Wei Qiu3  Min Zhang2  Zhongqiang Guo3  Boxing Su3  Jie Liu3  Xuesong Li3  | |
[1] Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, FuWai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China; E-Mail:;Department of Urology, Shanxi Medical University First Hospital, Taiyuan 030001, China; E-Mail:;Department of Urology, Peking University First Hospital & the Institute of Urology, Peking University, Beijing 100034, China; E-Mails: | |
关键词: kaempferol; bladder cancer; apoptosis; PTEN; Akt; | |
DOI : 10.3390/ijms141121215 | |
来源: mdpi | |
【 摘 要 】
Kaempferol (Kae), a natural flavonoid, is widely distributed in fruits and vegetables. Previous studies have identified Kae as a possible cancer preventive and therapeutic agent. We found Kae to exhibit potent antiproliferation and anti-migration effects in human bladder cancer EJ cells. Kaempferol robustly induced apoptosis in EJ cells in a dose-dependent manner, as evidenced by increased cleavage of caspase-3. Furthermore, we found Kae-induced apoptosis in EJ cells to be associated with phosphatase and the tensin homolog deleted on the chromosome 10 (PTEN)/PI3K/Akt pathway. Kae significantly increased PTEN and decreased Akt phosphorylation. Kae-induced apoptosis was partially attenuated in PTEN-knockdown cells. Our findings indicate that Kae could be an alternative medicine for bladder cancer, based on a PTEN activation mechanism.
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
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