Nutrients | |
Vitamin B12 Deficiency in Relation to Functional Disabilities | |
Breanna S. Oberlin2  Christy C. Tangney1  Kristin A. R. Gustashaw1  | |
[1] Department of Clinical Nutrition, Rush University Medical Center, 1700 West Van Buren St., Suite 425, Chicago, IL 60612, USA; E-Mails:;Diabetes Research Group, Seattle Institute of Biomedical and Clinical Research, 1660 S. Columbian Way, DPP-151, Seattle, WA 98108, USA; E-Mail: | |
关键词: vitamin B12 deficiency; methylmalonic acid; homocysteine; peripheral neuropathy; functional impairment; | |
DOI : 10.3390/nu5114462 | |
来源: mdpi | |
【 摘 要 】
This study was designed to assess whether symptoms, functional measures, and reported disabilities were associated with vitamin B12 (B12) deficiency when defined in three ways. Participants, aged 60 or more years of age, in 1999–2002 National Health and Nutrition Examination Surveys (NHANES) were categorized in relation to three previously used definitions of B12 deficiency: (1) serum B12 < 148 pmol/L; (2) serum B12 < 200 pmol/L and serum homocysteine > 20 μmol/L; and (3) serum B12 < 258 pmol/L or serum methylmalonic acid > 0.21 μmol/L. Functional measures of peripheral neuropathy, balance, cognitive function, gait speed, along with self-reported disability (including activities of daily living) were examined with standardized instruments by trained NHANES interviewers and technicians. Individuals identified as B12 deficient by definition 2 were more likely to manifest peripheral neuropathy OR (odds) (95% confidence intervals),
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190031816ZK.pdf | 400KB | download |