Bioactive Quinic Acid Derivatives from Ageratina adenophora

Molecules

Mei Zhang²  Wan-Xue Liu¹  Meng-Fei Zheng²  Qiao-Lin Xu³  Fang-Hao Wan¹  Jing Wang²  Ting Lei²  Zhong-Yu Zhou² 

[1] State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China;Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;Biotechnology Division, Guangdong Academy of Forestry, Guangzhou 510520, China

关键词: Ageratina adenophora;    qunic acid;    antimicrobial activity;    radical scavenging capacity;    DPPH;   

DOI  :  10.3390/molecules181114096

来源: mdpi

【 摘 要 】

A novel quinic acid derivative, 5-O-trans-o-coumaroylquinic acid methyl ester (1), together with three known ones, chlorogenic acid methyl ester (2), macranthoin F (3) and macranthoin G (4), were isolated from the aerial parts of the invasive plant Ageratina adenophora (Spreng.). The structure of new compound 1 was elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 2–4 were isolated from plant A. adenophora for the first time. All the compounds showed in vitro antibacterial activity toward five assayed bacterial strains, especially 3 and 4, which showed in vitro antibacterial activity against Salmonella enterica with MIC values of 7.4 and 14.7 μM, respectively. Compound 1 was further found to display in vitro anti-fungal activity against spore germination of Magnaporthe grisea with an IC₅₀ value 542.3 µM. These four compounds were also tested for their antioxidant activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radical.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.