Oats in the Diet of Children with Celiac Disease: Preliminary Results of a Double-Blind, Randomized, Placebo-Controlled Multicenter Italian Study

Nutrients

Simona Gatti⁷  Nicole Caporelli⁷  Tiziana Galeazzi⁷  Ruggiero Francavilla⁴  Maria Barbato¹  Paola Roggero³  Basilio Malamisura⁵  Giuseppe Iacono²  Andrea Budelli⁶  Rosaria Gesuita⁸  Carlo Catassi⁷ 

[1] Department of Pediatrics, “Sapienza” University of Rome, 00161 Roma, Italy; E-Mail:;Pediatric Gastroenterology Unit, “G. Di Cristina” Children Hospital, 90134 Palermo, Italy; E-Mail:;Neonatal Intensive Care Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, 20122 Milano, Italy; E-Mail:;Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy; E-Mail:;Department of Pediatrics, S. Maria dell’Olmo Hospital Cava de’ Tirreni, 84013 Salerno, Italy; E-Mail:;R&D Heinz Italia S.p.A, 04100 Latina, Italy; E-Mail:;Department of Pediatrics, Università Politecnica delle Marche, 60121 Ancona, Italy; E-Mails:;Department of Epidemiology, Biostatistics and Medical Information Technology, Università Politecnica delle Marche, 60121 Ancona, Italy; E-Mail:

关键词: : oats;    celiac disease;    gluten-free diet;    intestinal permeability;    gastrointestinal symptoms;   

DOI  :  10.3390/nu5114653

来源: mdpi

【 摘 要 】

A gluten-free diet (GFD) is currently the only available treatment for patients with celiac disease (CD). Several clinical trials have demonstrated that most celiac patients can tolerate a medium-high quantity of oats without any negative clinical effects; however, the inclusion of oats in GFD is still a matter of debate. In this study, Italian children with CD were enrolled in a 15-month, randomized, double-blind, placebo-controlled multicenter trial. Participants were randomized in two groups following either A-B treatment (6 months of diet “A”, 3 months of standard GFD, 6 months of diet “B”), or B-A treatment (6 months of diet “B”, 3 months of standard GFD, 6 months of diet “A”). A and B diets included gluten-free (GF) products (flour, pasta, biscuits, cakes and crisp toasts) with either purified oats or placebo. Clinical data (Gastrointestinal Symptoms Rate Scale [GSRS] score) and intestinal permeability tests (IPT), were measured through the study period. Although the study is still blinded, no significant differences were found in GSRS score or the urinary lactulose/mannitol (L/M) ratio between the two groups after 6 months of treatment. These preliminary results suggest that the addition of non-contaminated oats from selected varieties in the treatment of children with CD does not determine changes in intestinal permeability and gastrointestinal symptoms.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.