Synthesis and Binding Ability of Molecular Probes Based on a Phenanthroline Derivative: Theory and Experiment

Molecules

Xuefang Shang²  Yingling Wang²  Xiaofang Wei¹  Zhiyuan Fu¹  Jinlian Zhang¹ 

[1] School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan, China;Department of Chemistry, Xinxiang Medical University, Xinxiang 453003, Henan, China

关键词: synthesis;    fluorescent probe;    colorimetric recognition;    theoretical investigation;    phenanthroline derivative;   

DOI  :  10.3390/molecules181214840

来源: mdpi

【 摘 要 】

A fluorescent and colorimetric molecular probe containing phenol groups has been designed and synthesized. The anion binding ability was evaluated for biolgically important anions (F⁻, Cl⁻, Br⁻, I⁻, AcO⁻ and H₂PO₄⁻) by theoretical investigation, UV-Vis and fluorescence spectroscopy and ¹H-NMR titration experiments. Results indicated the probe showed strong binding ability for H₂PO₄⁻ without the interference of other anions tested and the interaction process was accompanied by color changes. Theoretical investigation analysis revealed that intramolecular hydrogen bonds existed in the structure of the probe and the roles of molecular frontier orbitals in molecular interplay were determined.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.