Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths

Molecules

Nihar Ranjan¹ 

[1] Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USA; E-Mail

关键词: G-quadruplex;    neomycin;    Hoechst 33258;    oncogenes;    FID;    C-myc;   

DOI  :  10.3390/molecules181114228

来源: mdpi

【 摘 要 】

G-quadruplexes are therapeutically important biological targets. In this report, we present biophysical studies of neomycin-Hoechst 33258 conjugates binding to a G-quadruplex derived from the C-myc promoter sequence. Our studies indicate that conjugation of neomycin to a G-quadruplex binder, Hoechst 33258, enhances its binding. The enhancement in G-quadruplex binding of these conjugates varies with the length and composition of the linkers joining the neomycin and Hoechst 33258 units.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.