期刊论文详细信息
【 摘 要 】
Non-intercalating DNA minor-groove binders may effectively inhibit the supercoiling activity of gyrases by influencing the enzyme recognition and cleavage site on DNA. For gyrase from Streptomyces noursei a wide range of inhibitory potency for different classes of ligands is observed. This can be explained by a number of structural and binding factors of the ligands competing with the gyrase on the target site of DNA, the mechanism of which is different from the classical gyrase inhibitors.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020297474ZK.pdf | 642KB | ![]() |