Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

Molecules

Tran Dinh Thang¹  Ping-Chung Kuo⁴  Tsong-Long Hwang²  Mei-Lin Yang³  Nguyen Thi Bich Ngoc¹  Tran Thi Ngoc Han¹  Chi-Wen Lin⁴ 

[1] Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam; E-Mails:;Graduate Institute of Natural Products and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan; E-Mail:;Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan; E-Mails:

关键词: Ganoderma;    triterpenoid;    steroid;    superoxide anion generation;    elastase release;   

DOI  :  10.3390/molecules181114285

来源: mdpi

【 摘 要 】

The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC₅₀ values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.