Characterization of Flavonoids in the Ethomedicine Fordiae Cauliflorae Radix and Its Adulterant Millettiae Pulchrae Radix by HPLC-DAD-ESI-IT-TOF-MSn

Molecules

Lan-Lan Fan¹  Tao Yi¹  Feng Xu²  Ya-Zhou Zhang³  Jian-Ye Zhang¹  Dian-Peng Li⁵  Yang-Jiao Xie⁴  Shan-Ding Qin³ 

[1] School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China;School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;Guangxi Botanical Garden of Medicinal Plant, Nanning, Guangxi 530023, China;School of Pharmacy, Guangxi University of Chinese Medicine, Guangxi 530001, China;Guangxi Institute of Botany, the Chinese Academy of Science, Guilin, Guangxi 541006, China

关键词: Fordia cauliflora;    Millettia pulchra var. laxior;    HPLC-DAD-ESI-IT-TOF-MSⁿ;    flavonoids;    identification;    ethnomedicine;   

DOI  :  10.3390/molecules181215134

来源: mdpi

【 摘 要 】

Fordiae Cauliflorae Radix (FC, the root of Fordia cauliflora Hemsl) and Millettiae Pulchrae Radix [MP, the root of Millettia pulchra (Benth.) Kurz var. laxior (Dunn) Z. Wei], which go under the same local name of “Daluosan”, have long been used in Southern China for the treatment of stroke, paralysis, dementia in children, Alzheimer’s disease and other diseases. The same local name and similar functions always confuse users. To further utilize these two ethnodrugs and identify them unambiguously, an HPLC-DAD-ESI-IT-TOF-MSⁿ method was developed to separate and characterize the flavonoids in FC and MP. A total of 41 flavonoids were detected, of which six compounds were identified by comparing their retention time and MS data with those of the reference standards, and the others were tentatively identified based on their tandem mass spectrometry data obtained in the positive ion detection mode. Nineteen of these characterized compounds are reported from these two plants for the first time.

【 授权许可】

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.