C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and Their Pharmacological Activities

Molecules

Giovanni Di Fabio²  Valeria Romanucci²  Mauro Zarrelli¹  Michele Giordano¹ 

[1] IMCB-Institute of Composite and Biomedical Materials CNR–National Research Council P E Fermi, (Granatello) Portici, Napoli 80055, Italy; E-Mails:;Department of Chemical Sciences, University Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, Napoli 80126, Italy; E-Mails:

关键词: Gymnema sylvestre;    triterpenoids;    oleanes;    pharmacological activities;    phytochemistry;   

DOI  :  10.3390/molecules181214892

来源: mdpi

【 摘 要 】

Gymnema sylvestre R. Br., one of the most important medicinal plants of the Asclepiadaceae family, is a herb distributed throughout the World, predominantly in tropical countries. The plant, widely used for the treatment of diabetes and as a diuretic in Indian proprietary medicines, possesses beneficial digestive, anti-inflammatory, hypoglycemic and anti-helmentic effects. Furthermore, it is believed to be useful in the treatment of dyspepsia, constipation, jaundice, hemorrhoids, cardiopathy, asthma, bronchitis and leucoderma. A literature survey revealed that some other notable pharmacological activities of the plant such as anti-obesity, hypolipidemic, antimicrobial, free radical scavenging and anti-inflammatory properties have been proven too. This paper aims to summarize the chemical and pharmacological reports on a large group of C-4 gem-dimethylated pentacyclic triterpenoids from Gymnema sylvestre.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.