New Pregnane Glycosides from Gymnema sylvestre

Molecules

Rui Xu²  Yu Yang²  Yang Zhang²  Fengxia Ren²  Jinlong Xu²  Nengjiang Yu¹  Yimin Zhao¹ 

[1] Institute of Pharmacology and Toxicology, Academy for Military Medical Science, 27 Taiping Road, Haidian District, Beijing 100850, China;

关键词: Gymnema sylvestre;    Asclepiadaceae;    pregnane glycosides;    α-glucosidase;   

DOI  :  10.3390/molecules20023050

来源: mdpi

【 摘 要 】

Four new pregnane glycosides 1–4 were isolated from the ethanol extract of the stem of Gymnema sylvestre and named gymsylvestrosides A–D. Hydrolysis of compound 1 under the catalysis of Aspergilus niger β-glucosidase afforded compound 5 (gymsylvestroside E). Their structures were determined by spectroscopic methods such as HRESIMS, 1D and 2D NMR, as well as HMQC-TOCSY experiment. Compounds 1–4 were screened for Saccharomyces cerevisiae α-glucosidase inhibitory activity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.