PTEN, Longevity and Age-Related Diseases

Biomedicines

Izak S. Tait¹  Yan Li¹ 

[1] School of Applied Sciences, Auckland University of Technology, WS306, WS Building, City Campus, St Paul Street, Auckland 1010, New Zealand; E-Mails:

关键词: PTEN;    aging;    longevity;    caloric;    restriction;    DNA;    damage;    gene;   

DOI  :  10.3390/biomedicines1010017

来源: mdpi

【 摘 要 】

Since the discovery of PTEN, this protein has been shown to be an effective suppressor of cancer and a contributor to longevity. This report will review, in depth, the associations between PTEN and other molecules, its mutations and regulations in order to present how PTEN can be used to increase longevity. This report will collect recent research of PTEN and use this to discuss PTEN’s role in caloric restriction, antioxidative defense of DNA-damage and the role it plays in suppressing tumors. The report will also discuss that variety of ways that PTEN can be compromised, through mutations, complete loss of alleles and its main antagonist, the PI3K/AKT pathway.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.