Bone Regeneration of Rat Tibial Defect by Zinc-Tricalcium Phosphate (Zn-TCP) Synthesized from Porous Foraminifera Carbonate Macrospheres

Marine Drugs

Joshua Chou²  Jia Hao¹  Shinji Kuroda¹  David Bishop³  Besim Ben-Nissan³  Bruce Milthorpe³ 

[1] Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; E-Mails:;Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, 1-1-20 Shin-machi, Nishitokyo-Shi, Tokyo 202-8585, Japan; E-Mail:;Faculty of Science, University of Technology Sydney, P.O. Box 123, Broadway, Ultimo, Sydney, NSW 2007, Australia; E-Mails:

关键词: biomimetic;    zinc-tricalcium phosphate;    foraminifera;    bone defect;    bone regeneration;   

DOI  :  10.3390/md11125148

来源: mdpi

【 摘 要 】

Foraminifera carbonate exoskeleton was hydrothermally converted to biocompatible and biodegradable zinc-tricalcium phosphate (Zn-TCP) as an alternative biomimetic material for bone fracture repair. Zn-TCP samples implanted in a rat tibial defect model for eight weeks were compared with unfilled defect and beta-tricalcium phosphate showing accelerated bone regeneration compared with the control groups, with statistically significant bone mineral density and bone mineral content growth. CT images of the defect showed restoration of cancellous bone in Zn-TCP and only minimal growth in control group. Histological slices reveal bone in-growth within the pores and porous chamber of the material detailing good bone-material integration with the presence of blood vessels. These results exhibit the future potential of biomimetic Zn-TCP as bone grafts for bone fracture repair.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.