In Vitro Screening of the Apatite-Forming Ability, Biointeractivity and Physical Properties of a Tricalcium Silicate Material for Endodontics and Restorative Dentistry

Dentistry Journal

Maria Giovanna Gandolfi¹  Francesco Siboni¹  Antonella Polimeni³  Maurizio Bossù³  Francesco Riccitiello²  Sandro Rengo² 

[1] Laboratory of Biomaterials and Oral Pathology (Unit of Odontostomatological Sciences), Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, 40125, Italy; E-Mail:;Department of Oral and Maxillofacial Sciences, University of Napoli Federico II, Napoli, 80131, Italy; E-Mails:;Unit of Paediatric Dentistry, Department of Oral and Maxillofacial Sciences, University of Rome, Sapienza, 00161, Rome, Italy; E-Mails:

关键词: calcium silicate cements;    tricalcium silicate;    Biodentine;    ProRoot MTA;    calcium release;    calcium hydroxide;    calcium phosphate deposits;    porosity;    solubility;    water sorption;    microanalysis;   

DOI  :  10.3390/dj1040041

来源: mdpi

【 摘 要 】

Aim: Calcium silicate-based materials are hydraulic self-setting materials with physico-chemical properties suitable for endodontic surgery and good biological/clinical outcomes. The study aim was to evaluate the bio-properties (biointeractivity and apatite-forming ability) and selected physical properties (porosity, water sorption, solubility, and setting time) of Biodentine, a tricalcium silicate material for endodontics and restorative dentistry, compared to that of ProRoot MTA (Mineral Trioxide Aggregate) as gold standard material. Methods: Biodentine and ProRoot MTA pastes were prepared and analyzed for calcium release and alkalinizing activity (3 h–28 days), setting time, water sorption, porosity, solubility, surface microstructure and composition, and apatite-forming ability in simulated body fluid. Results: Biodentine showed higher calcium release, alkalinizing activity, and solubility but higher open and apparent porosity, water sorption, and a markedly shorter setting time. Calcium phosphate (CaP) deposits were noted on material surfaces after short ageing times. A CaP coating composed of spherulites was detected after 28 days. The thickness, continuity, and Ca/P ratio of the coating differed markedly between the materials. Biodentine showed a coating composed by denser but smaller spherulites, while ProRoot MTA showed large but less dense aggregates of spherulitic deposits. Conclusions: Biodentine showed a pronounced ability to release calcium and extended alkalinizing activity interlinked with its noticeable porosity, water sorption, and solubility: open porosities provide a broad wet biointeractive surface for the release of the calcium and hydroxyl ions involved in the formation of a CaP mineral. Biodentine is a biointeractive tricalcium silicate material with interesting chemical-physical properties and represents a fast-setting alternative to the conventional calcium silicate MTA-like cements.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.