Molecules | |
Protective Effects of Quercetin and Quercetin-5',8-Disulfonate against Carbon Tetrachloride-Caused Oxidative Liver Injury in Mice | |
Yanmang Cui1  Yong Han1  Xingbin Yang2  Yanfei Sun2  | |
[1] School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China;College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710062, China | |
关键词: quercetin; quercetin-5'; 8-disulfonate; hepatoprotective effects; HPLC; absorption; | |
DOI : 10.3390/molecules19010291 | |
来源: mdpi | |
【 摘 要 】
Oxidative stress is one of the major factors in the pathogenesis of liver disease. Quercetin is a plant-based antioxidant traditionally used as a treatment for hepatic injury, but its poor solubility affects its bioavailability. We here report the regulative effects on hepatoprotection and absorption in mice of quercetin sulfation to form quercetin-5',8-disulfonate (QS), a novel synthetic compound. Oral administration of both QS and the parent quercetin at 100, 200 and 500 mg/kg·bw prior to acute CCl4 oxidative damage in mice, effectively attenuated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities and hepatic malondialdehyde (MDA) levels (
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190030291ZK.pdf | 1226KB | download |