Development of Streptococcus pneumoniae Vaccines Using Live Vectors

Vaccines

Shifeng Wang¹ 

[1] Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA

关键词: Streptococcus pneumoniae;    Salmonella;    lactic acid bacteria;    BCG;    adenoviruses;    bacterial vector;    viral vector;   

DOI  :  10.3390/vaccines2010049

来源: mdpi

【 摘 要 】

Streptococcus pneumoniae still causes severe morbidity and mortality worldwide, especially in young children and the elderly. Much effort has been dedicated to developing protein-based universal vaccines to conquer the current shortcomings of capsular vaccines and capsular conjugate vaccines, such as serotype replacement, limited coverage and high costs. A recombinant live vector vaccine delivering protective antigens is a promising way to achieve this goal. In this review, we discuss the researches using live recombinant vaccines, mainly live attenuated Salmonella and lactic acid bacteria, to deliver pneumococcal antigens. We also discuss both the limitations and the future of these vaccines.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.