Maize Purple Plant Pigment Protects Against Fluoride-Induced Oxidative Damage of Liver and Kidney in Rats

International Journal of Environmental Research and Public Health

Zhuo Zhang²  Bo Zhou¹  Hiaohong Wang¹  Fei Wang²  Yingli Song²  Shengnan Liu² 

[1] Department of Nutrition and Food Hygiene, Shenyang Medical College, No146 Huanghe North Street, Shenyang 110034, China; E-Mails:;Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 92 Bei Er Road, Heping District, Shenyang 110001, China; E-Mails:

关键词: fluoride;    oxidative stress;    anthocyanins;    maize purple plant pigment;    rats;   

DOI  :  10.3390/ijerph110101020

来源: mdpi

【 摘 要 】

Anthocyanins are polyphenols and well known for their biological antioxidative benefits. Maize purple plant pigment (MPPP) extracted and separated from maize purple plant is rich in anthocyanins. In the present study, MPPP was used to alleviate the adverse effects generated by fluoride on liver and kidney in rats. The results showed that the ultrastructure of the liver and kidney in fluoride treated rats displayed shrinkage of nuclear and cell volume, swollen mitochondria and endoplasmic reticulum and vacuols formation in the liver and kidney cells. MPPP significantly attenuated these fluoride-induced pathological changes. The MDA levels in serum and liver tissue of fluoride alone treated group were significantly higher than those of the control group (p < 0.05). The presence of 5 g/kg MPPP in the diet reduced the elevation of MDA levels in blood and liver, and increased the SOD and GSH-Px activities in kidney and GSH level in liver and kidney compared with the fluoride alone treated group (p < 0.05). In addition, MPPP alleviated the decrease of Bcl-2 protein expression and the increase of Bax protein expression induced by fluoride. This study demonstrated the protective role of MPPP against fluoride-induced oxidative stress in liver and kidney of rats.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.