International Journal of Molecular Sciences | |
Modulation of Cyclins, p53 and Mitogen-Activated Protein Kinases Signaling in Breast Cancer Cell Lines by 4-(3,4,5-Trimethoxyphenoxy)benzoic Acid | |
Kuan-Han Lee3  Wen-Yueh Ho5  Shu-Jing Wu6  Hany A. Omar4  Po-Jui Huang1  Clay C. C. Wang2  | |
[1] Department of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan; E-Mail:;Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, CA 90089, USA; E-Mail:;Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan; E-Mail:;Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; E-Mail:;Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan; E-Mail:;Department of Nutritional Health, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan; E-Mail: | |
关键词: 4-(3; 4; 5-trimethoxyphenoxy)benzoic acid; MCF-7; MDA-468; apoptosis; MAPK kinases; p53; cyclins; | |
DOI : 10.3390/ijms15010743 | |
来源: mdpi | |
【 摘 要 】
Despite the advances in cancer therapy and early detection, breast cancer remains a leading cause of cancer-related deaths among females worldwide. The aim of the current study was to investigate the antitumor activity of a novel compound, 4-(3,4,5-trimethoxyphenoxy)benzoic acid (TMPBA) and its mechanism of action, in breast cancer. Results indicated the relatively high sensitivity of human breast cancer cell-7 and MDA-468 cells towards TMPBA with
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
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