International Journal of Molecular Sciences | |
Genomic and Phenotypic Alterations of the Neuronal-Like Cells Derived from Human Embryonal Carcinoma Stem Cells (NT2) Caused by Exposure to Organophosphorus Compounds Paraoxon and Mipafox | |
David Pamies2  Miguel A. Sogorb2  Marco Fabbri1  Laura Gribaldo1  Angelo Collotta1  Bibiana Scelfo1  Eugenio Vilanova2  Georgina Harris1  | |
[1] Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Varese 21027, Italy; E-Mails:;Bioengineering Institute, Miguel Hernández University, Elche 03202, Alicante, Spain; E-Mails: | |
关键词: neurodifferentiation; neurodevelopmental toxicity; NT2; organophosphorus pesticides; NTE; human embryonal carcinoma stem cells; | |
DOI : 10.3390/ijms15010905 | |
来源: mdpi | |
【 摘 要 】
Historically, only few chemicals have been identified as neurodevelopmental toxicants, however, concern remains, and has recently increased, based upon the association between chemical exposures and increased developmental disorders. Diminution in motor speed and latency has been reported in preschool children from agricultural communities. Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited. Other neurological and neurodevelopmental toxic effects with unknown targets have been reported after chronic exposure to OPs
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
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RO202003190029933ZK.pdf | 779KB | download |