Incorporating β-Cyclodextrin with ZnO Nanorods: A Potentiometric Strategy for Selectivity and Detection of Dopamine

Sensors

Sami Elhag¹  Zafar Hussain Ibupoto²  Omer Nur² 

[1] Department of Science and Technology, Campus Norrköping, Linköping University, Norrköping SE-60174, Sweden;

关键词: ZnO nanorods;    dopamine;    potentiometric response;    selectivity;    stability;    repeatability;   

DOI  :  10.3390/s140101654

来源: mdpi

【 摘 要 】

We describe a chemical sensor based on a simple synthesis of zinc oxide nanorods (ZNRs) for the detection of dopamine molecules by a potentiometric approach. The polar nature of dopamine leads to a change of surface charges on the ZNR surface via metal ligand bond formation which results in a measurable electrical signal. ZNRs were grown on a gold-coated glass substrate by a low temperature aqueous chemical growth (ACG) method. Polymeric membranes incorporating β-cyclodextrin (β-CD) and potassium tetrakis (4-chlorophenyl) borate was immobilized on the ZNR surface. The fabricated electrodes were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. The grown ZNRs were well aligned and exhibited good crystal quality. The present sensor system displays a stable potential response for the detection of dopamine in 10⁻² mol·L⁻¹ acetic acid/sodium acetate buffer solution at pH 5.45 within a wide concentration range of 1 × 10⁻⁶ M⁻¹ × 10⁻¹ M, with sensitivity of 49 mV/decade. The electrode shows a good response time (less than 10 s) and excellent repeatability. This finding can contribute to routine analysis in laboratories studying the neuropharmacology of catecholamines. Moreover, the metal-ligand bonds can be further exploited to detect DA receptors, and for bio-imaging applications.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.