International Journal of Molecular Sciences | |
Yaxue Zhao2  Qingqing Meng2  Linquan Bai1  | |
[1] State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; E-Mail:;School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; E-Mails: | |
关键词: aminoacyl-tRNA synthetase; inhibitor; antibiotics; virtual screening; structure-based drug design; docking; | |
DOI : 10.3390/ijms15011358 | |
来源: mdpi | |
【 摘 要 】
Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review, we mainly focused on aaRS inhibitor discovery and development using
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
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