Biocompatibility of Poly(ester amide) (PEA) Microfibrils in Ocular Tissues

Polymers

Martina Kropp²  Katharina-Marie Morawa¹  George Mihov³  Anna Katharina Salz⁴  Nina Harmening²  Astrid Franken³  Anja Kemp³  Aylvin A. Dias³  Jens Thies³  Sandra Johnen⁴ 

[1] Department of Ophthalmology, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany; E-Mail:;Department of Vitreoretinal Surgery, University Hospitals of Geneva, Rue Alcide-Jentzer 22, 1205 Geneva, Switzerland; E-Mails:;DSM, Urmonderbaan 22, Geleen 6167 RD, The Netherlands; E-Mails:;Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Aachen, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany; E-Mails:

关键词: biomaterials;    biodegradation;    drug delivery;    controlled drug release;    amino acid;   

DOI  :  10.3390/polym6010243

来源: mdpi

【 摘 要 】

Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by surface erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by surface erosion.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.