International Journal of Molecular Sciences | |
shRNA-Mediated |
|
Qin Wang2  Yan Wang2  Liqing Du2  Chang Xu2  Yuanming Sun2  Bing Yang1  Zhijuan Sun2  Yue Fu2  Lu Cai3  Saijun Fan2  Feiyue Fan2  | |
[1] Department of Cell Biology, Tianjin Medical University, Tianjin 300070, China; E-Mail:;Tianjin Key Lab of Molecular Nuclear Medicine, Institute of Radiation Medicine of Chinese, Academy of Medical Science and Peking Union Medical College, Tianjin 300192, China; E-Mails:;Department of Pediatrics of University of Louisville, Louisville, KY 40202, USA; E-Mail: | |
关键词: XRCC2; RNA interference; colon cancer; ionizing radiation; radiosensitivity; | |
DOI : 10.3390/ijms15022157 | |
来源: mdpi | |
【 摘 要 】
Colon cancer is one of the most common tumors of the digestive tract. Resistance to ionizing radiation (IR) decreased therapeutic efficiency in these patients’ radiotherapy. XRCC2 is the key protein of DNA homologous recombination repair, and its high expression is associated with enhanced resistance to DNA damage induced by IR. Here, we investigated the effect of
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
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