Matrix Metalloproteinases: The Gene Expression Signatures of Head and Neck Cancer Progression

Cancers

Shinji Iizuka²  Naozumi Ishimaru¹ 

[1] Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-8-15 Kuramoto, Tokushima 770-8504, Japan; E-Mail:;Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; E-Mail:

关键词: matrix metalloproteinase;    invasion;    angiogenesis;    head and neck squamous cell carcinoma;   

DOI  :  10.3390/cancers6010396

来源: mdpi

【 摘 要 】

Extracellular matrix degradation by matrix metalloproteinases (MMPs) plays a pivotal role in cancer progression by promoting motility, invasion and angiogenesis. Studies have shown that MMP expression is increased in head and neck squamous cell carcinomas (HNSCCs), one of the most common cancers in the world, and contributes to poor outcome. In this review, we examine the expression pattern of MMPs in HNSCC by microarray datasets and summarize the current knowledge of MMPs, specifically MMP-1, -3, -7 -10, -12, -13, 14 and -19, that are highly expressed in HNSCCs and involved cancer invasion and angiogenesis.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.