Experimental Simulation of the Effects of an Initial Antibiotic Treatment on a Subsequent Treatment after Initial Therapy Failure

Antibiotics

Yanfang Feng¹  Nadine Händel¹  Marnix H. P. de Groot¹  Stanley Brul¹  Constance Schultsz² 

[1] Laboratory for Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands; E-Mails:;Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; E-Mail:

关键词: therapy failure;    resistance development;    amoxicillin;    cefotaxime;   

DOI  :  10.3390/antibiotics3010049

来源: mdpi

【 摘 要 】

Therapy failure of empirical antibiotic treatments prescribed by primary care physicians occurs commonly. The effect of such a treatment on the susceptibility to second line antimicrobial drugs is unknown. Resistance to amoxicillin was rapidly induced or selected in E. coli at concentrations expected in the patient’s body. Strains with reduced susceptibility outcompeted the wild-type whenever antibiotics were present, even in low concentrations that did not affect the growth rates of both strains. Exposure of E. coli to amoxicillin caused moderate resistance to cefotaxime. The combined evidence suggests that initial treatment by amoxicillin has a negative effect on subsequent therapy with beta-lactam antibiotics.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.