Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana

Molecules

Zeng Xu³  Lei Huang³  Xiao-Hong Chen⁴  Xiao-Feng Zhu¹  Xiao-Jun Qian¹  Gong-Kan Feng¹  Wen-Jian Lan² 

[1] State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China; E-Mails:;School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China;School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China; E-Mails:;Instrumental Analysis and Research Center, Sun Yat-Sen University, Guangzhou 510275, China; E-Mail:

关键词: Garcinia mangostana;    xanthones;    cytotoxic activities;   

DOI  :  10.3390/molecules19021820

来源: mdpi

【 摘 要 】

Bioassay-guided fractionation of an ethanol extract of the pericarps of Garcinia mangostana led to the isolation of two new prenylated xanthones, named 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone (1) and 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), together with the five known compounds garcinones C (3) and D (4), gartanin (5), xanthone I (6), and γ-mangostin (7). Their structures were elucidated primarily based on MS and NMR data. Compounds 1–7 showed significant cytotoxic activities against various human cancer cell lines.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.