Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness

Toxins

Frederick T. Guilford¹ 

[1] Your Energy Systems, LLC 555 Bryant St. #305, Palo Alto, CA 94301, USA

关键词: glutathione;    mycotoxin;    aflatoxin;    ochratoxin;    trichothecene;    Nrf2 modification;    genetic polymorphism;    oxidative stress;   

DOI  :  10.3390/toxins6020608

来源: mdpi

【 摘 要 】

Evidence for the role of oxidative stress in the pathophysiology of mycotoxin-related illness is increasing. The glutathione antioxidant and detoxification systems play a major role in the antioxidant function of cells. Exposure to mycotoxins in humans requires the production of glutathione on an “as needed” basis. Research suggests that mycotoxins can decrease the formation of glutathione due to decreased gene expression of the enzymes needed to form glutathione. Mycotoxin-related compromise of glutathione production can result in an excess of oxidative stress that leads to tissue damage and systemic illness. The review discusses the mechanisms by which mycotoxin-related deficiency of glutathione may lead to both acute and chronic illnesses.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.