Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Molecules

Peng Wang²  Hui-Hui Yuan¹  Xue Zhang²  Yun-Ping Li¹  Lu-Qing Shang² 

[1] College of Life Sciences, Nankai University, Tianjin 300071, China;College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

关键词: lycorine derivatives;    anticancer;    synthesis;   

DOI  :  10.3390/molecules19022469

来源: mdpi

【 摘 要 】

Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.