International Journal of Molecular Sciences | |
Expression of PHB2 in Rat Brain Cortex Following Traumatic Brain Injury | |
Ting Xu3  Xinjuan Fan2  Yuanyuan Tan1  Ying Yue1  Weijie Chen1  | |
[1] Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China; E-Mails:;Affiliated Hospital of Nantong University, Nantong 226001, China; E-Mail:;The Center Laboratory of Huai’an First People’s Hospital Nanjing Medical University, Huai’an 223300, China; E-Mail: | |
关键词: traumatic brain injury; Prohibitin2; neuron; astrocyte; proliferation; apoptosis; | |
DOI : 10.3390/ijms15023299 | |
来源: mdpi | |
【 摘 要 】
Prohibitin2 (PHB2) is a ubiquitous, evolutionarily strongly conserved protein. It is one of the components of the prohibitin complex, which comprises two highly homologous subunits, PHB1 and PHB2. PHB2 is present in various cellular compartments including the nucleus and mitochondria. Recent studies have identified PHB2 as a multifunctional protein that controls cell proliferation, apoptosis, cristae morphogenesis and the functional integrity of mitochondria. However its distribution and function in the central nervous system (CNS) are not well understood. In this study, we examined PHB2 expression and cellular localization in rats after acute traumatic brain injury (TBI). Western Blot analysis showed PHB2 level was significantly enhanced at five days after injury compared to control, and then declined during the following days. The protein expression of
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190028730ZK.pdf | 1898KB | download |