Cross-talk between neurons and glia: highlights on soluble factors

Brazilian Journal of Medical and Biological Research

F.c.a. Gomes¹  T.c.l.s. Spohr¹  R. Martinez¹  V. Moura Neto¹ 

[1] ,Universidade Federal do Rio de Janeiro Departamento de Anatomia Instituto de Ciências BiomédicasRio de Janeiro RJ ,Brasil

关键词: neuron-glia interaction;    trophic factors;    astrocyte;    neuron;    nervous system;   

DOI  :  10.1590/S0100-879X2001000500008

来源: SciELO

【 摘 要 】

The development of the nervous system is guided by a balanced action between intrinsic factors represented by the genetic program and epigenetic factors characterized by cell-cell interactions which neural cells might perform throughout nervous system morphogenesis. Highly relevant among them are neuron-glia interactions. Several soluble factors secreted by either glial or neuronal cells have been implicated in the mutual influence these cells exert on each other. In this review, we will focus our attention on recent advances in the understanding of the role of glial and neuronal trophic factors in nervous system development. We will argue that the functional architecture of the brain depends on an intimate neuron-glia partnership.

【 授权许可】

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