The Genomic Signature of Breast Cancer Prevention

Genes

Jose Russo¹  Julia Santucci-Pereira² 

[1] The Irma H. Russo MD Breast Cancer Research Laboratory, Fox Chase Cancer Center, Temple University Health System, 333 Cottman Avenue, Philadelphia, PA 19111, USA; E-Mail

关键词: normal breast;    breast cancer;    genomic signature;    prevention;    pregnancy;    splicing mechanisms;    methylation;    chromatin remodeling;    Lnc-RNA;    beta-catenin;   

DOI  :  10.3390/genes5010065

来源: mdpi

【 摘 要 】

The breast of parous postmenopausal women exhibits a specific signature that has been induced by a full term pregnancy. This signature is centered in chromatin remodeling and the epigenetic changes induced by methylation of specific genes which are important regulatory pathways induced by pregnancy. Through the analysis of the genes found to be differentially methylated between women of varying parity, multiple positions at which beta-catenin production and use is inhibited were recognized. The biological importance of the pathways identified in this specific population cannot be sufficiently emphasized because they could represent a safeguard mechanism mediating the protection of the breast conferred by full term pregnancy.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.