Zearalenone, an Estrogenic Mycotoxin, Is an Immunotoxic Compound

Toxins

Isis M. Hueza¹  Paulo Cesar F. Raspantini²  Leonila Ester R. Raspantini²  Andreia O. Latorre² 

[1] Division of Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP–Diadema), Diadema 09913-030, S.P., Brazil;Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga 05508-270, S.P., Brazil; E-Mails:

关键词: zearalenone;    immunotoxicology;    endocrine disruptor;    estrogen receptor;    rats;   

DOI  :  10.3390/toxins6031080

来源: mdpi

【 摘 要 】

The aim of this study was to assess the toxic effects of zearalenone (ZEA) on the immune function. Ovariectomised rats were treated daily by gavage with 3.0 mg/kg of ZEA for 28 days. Body weight gain, food consumption, haemotological parameters, lymphoid organs, and their cellularities were evaluated. Moreover, acquired immune responses and macrophage activity were also assessed. ZEA promoted reduction in body weight gain, which is not fully explained by diminished food consumption. Despite no effect on haematological parameters, ZEA caused thymic atrophy with histological and thymocyte phenotype changes and decrease in the B cell percentage in the spleen. With respect to acquired and innate immune responses, no statistically significant differences in delayed-type hypersensitivity were noticed; however, in the ZEA-treated rats, antibody production and peroxide release by macrophages were impaired. The observed results could be related to ZEA activity on ERs; thus, ZEA is an immunotoxic compound similar to estrogen and some endocrine disruptors.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.