A Preliminary X-ray Study of Murine Tnfaip8/Oxi-α

International Journal of Molecular Sciences

Daeun Lee²  Mi-Sun Kim²  Jimin Park²  Gil-Ja Jhon¹  Jin H. Son² 

[1] Department of Chemistry and Nano Science, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea; E-Mail:;College of Pharmacy and Graduate School of Pharmaceutical Sciences, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea; E-Mails:

关键词: Parkinson’s disease;    Oxi-α;    oxidative stress;    C165S mutant;    X-ray crystallography;   

DOI  :  10.3390/ijms15034523

来源: mdpi

【 摘 要 】

Tnfaip8/oxidative stress regulated gene-α (Oxi-α) is a novel protein expressed specifically in brain dopaminergic neurons and its over-expression has been reported to protect dopaminergic cells against OS-induced cell death. In this study, murine C165S mutant Tnfaip8/Oxi-α has been crystallized and X-ray data have been collected to 1.8 Å using synchrotron radiation. The crystal belonged to the primitive orthorhombic space group P2₁2₁2, with unit-cell parameters a = 66.9, b = 72.3, c = 93.5 Å. A full structural determination is under way in order to provide insights into the structure-function relationships of this protein.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland