International Journal of Molecular Sciences | |
Potential Roles of Bone Morphogenetic Protein (BMP)-9 in Human Liver Diseases | |
Blanca Herrera2  Steven Dooley1  | |
[1]Department of Medicine II, Section Molecular Hepatology—Alcohol Associated Diseases, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany | |
[2] E-Mail: | |
[3]Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University of Madrid, San Carlos Clinical Hospital Health Research Institute (IdISSC), Madrid 28040, Spain | |
[4] E-Mail: | |
关键词: BMP-9; Hepatocellular carcinoma; signaling; physiology; liver; hepatocytes; hepatic stellate cells; angiogenesis; therapy; | |
DOI : 10.3390/ijms15045199 | |
来源: mdpi | |
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【 摘 要 】
Bone morphogenetic proteins (BMP-2 to BMP-15) belong to the Transforming Growth Factor (TGF)-β superfamily and, besides their well-documented roles during embryogenesis and bone formation, some of them have recently been described to be involved in the pathogenesis of different organs, including the liver. The role of BMPs in liver damage responses including hepatocellular carcinoma (HCC) development has only begun to be addressed and strong evidence supports the concept of a pro-tumorigenic role of BMP signaling in HCC cells. BMP-9 (also termed Growth and Differentiation Factor (GDF)-2) represents the most recently discovered member of the BMP family. We have previously demonstrated that in HCC patient samples BMP-9 expression was positively associated with the tumor seize (“T stage”) and that it enhanced cell migration and induced epithelial to mesenchymal transition (EMT) in HCC cells
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
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