Antibacterial Activity of New Oxazolidin-2-One Analogues in Methicillin-Resistant Staphylococcus aureus Strains

International Journal of Molecular Sciences

Jesús Córdova-Guerrero¹  Esteban Hernández-Guevara²  Sandy Ramírez-Zatarain²  Marco Nú༞z-Bautista¹  Adrián Ochoa-Terán²  Raquel Muñiz-Salazar¹  Julio Montes-Ávila³  Gabriela López-Angulo³  Armando Paniagua-Michel¹ 

[1] Escuela de Ciencias de la Salud, Universidad Autónoma de Baja California, Ensenada, Baja California 22890, México; E-Mails:;Centro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, Tijuana, Baja California 22000, México; E-Mails:;Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa 80010, México; E-Mails:

关键词: Staphylococcusaureus;    methicillin;    oxazolidin-2-ones;    antibacterial;   

DOI  :  10.3390/ijms15045277

来源: mdpi

【 摘 要 】

Staphylococcus aureus is one of the most common causes of nosocomial infections. The purpose of this study was the synthesis and in vitro evaluation of antimicrobial activity of 10 new 3-oxazolidin-2-one analogues on 12 methicillin resistant S. aureus (MRSA) clinical isolates. S. aureus confirmation was achieved via catalase and coagulase test. Molecular characterization of MRSA was performed by amplification of the mecA gene. Antimicrobial susceptibility was evaluated via the Kirby-Bauer disc diffusion susceptibility test protocol, using commonly applied antibiotics and the oxazolidinone analogues. Only (R)-5-((S)-1-dibenzylaminoethyl)-1,3-oxazolidin-2-one (7a) exhibited antibacterial activity at 6.6 μg. These results, allow us to infer that molecules such as 7a can be potentially used to treat infections caused by MRSA strains.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland