A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

Molecules

Karem Shanab²  Catharina Neudorfer¹  Wolfgang Holzer¹  Markus Mitterhauser²  Wolfgang Wadsak² 

[1] Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria;Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria

关键词: chemoselective;    alkylation;    microwave;    adenosine A3;    PET;    radiotracer;   

DOI  :  10.3390/molecules19044076

来源: mdpi

【 摘 要 】

The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [¹⁸F]FE@SUPPY [¹⁸F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2–8 in a single step.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.