International Journal of Molecular Sciences | |
Fatty Acid Elongation in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma | |
Sonja M. Kessler8  Yvette Simon8  Katja Gemperlein1  Kathrin Gianmoena7  Cristina Cadenas7  Vincent Zimmer2  Juliane Pokorny3  Ahmad Barghash6  Volkhard Helms6  Nico van Rooijen4  Rainer M. Bohle3  Frank Lammert2  Jan G. Hengstler7  Rolf Mueller1  Johannes Haybaeck5  | |
[1] Department of Pharmacy, Pharmaceutical Biotechnology, Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbrücken, Germany; E-Mails:;Department of Medicine II, Saarland University Medical Center, Kirrberger Str., 66421 Homburg, Germany; E-Mails:;Institute of Pathology, Saarland University, Kirrberger Str., 66421 Homburg, Germany; E-Mails:;Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands; E-Mail:;Institute of Pathology, Medical University of Graz, 8010 Graz, Austria; E-Mail:;Center for Bioinformatics, Saarland University, Campus E2 1, 66123 Saarbrücken, Germany; E-Mails:;Systems Toxicology, Leibniz Research Centre for Working Environment and Human Factors (IfADo) at the TU Dortmund, Ardeystr. 67, 44139 Dortmund, Germany; E-Mails:;Department of Pharmacy, Pharmaceutical Biology, Saarland University, Campus C2 2, 66123 Saarbrücken, Germany; E-Mails: | |
关键词:
diethylnitrosamine;
ELOVL6;
HCC;
hepatic steatosis;
leptin deficiency;
MCD;
non-alcoholic fatty liver disease (NAFLD);
|
|
DOI : 10.3390/ijms15045762 | |
来源: mdpi | |
【 摘 要 】
Non-alcoholic steatohepatitis (NASH) represents a risk factor for the development of hepatocellular carcinoma (HCC) and is characterized by quantitative and qualitative changes in hepatic lipids. Since elongation of fatty acids from C16 to C18 has recently been reported to promote both hepatic lipid accumulation and inflammation we aimed to investigate whether a frequently used mouse NASH model reflects this clinically relevant feature and whether C16 to C18 elongation can be observed in HCC development. Feeding mice a methionine and choline deficient diet to model NASH not only increased total hepatic fatty acids and cholesterol, but also distinctly elevated the C18/C16 ratio, which was not changed in a model of simple steatosis (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190027297ZK.pdf | 4527KB | download |